HCID 14330456, Verbindung → 5-Methoxy-3,4-dihydro-2H-1-benzothiopyran-3-amine

HRID 1073139Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1073139
C(OC([NH:8][CH:9]1[CH2:14][C:13]2[C:15]([O:19][CH3:20])=[CH:16][CH:17]=[CH:18][C:12]=2[S:11][CH2:10]1)=O)(C)(C)C>FC(F)(F)C(O)=O>[CH3:20][O:19][C:15]1[C:13]2[CH2:14][CH:9]([NH2:8])[CH2:10][S:11][C:12]=2[CH:18]=[CH:17][CH:16]=1

Komponenten

3

Edukt 1

HCID 14330456HCID 14330456, Verbindung

Produkt 1

HCID 143304585-Methoxy-3,4-dihydro-2H-1-benzothiopyran-3-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

A solution of 10 g of N-t-butoxycarbonyl-3,4-di-hydro-5-methoxy-2H-[1]-benzothiopyran-3-amine in 30 ml of trifluoroacetic acid is kept at room temperature for 1 hour. The solvent is removed in vacuo, the residue is treated with 1N NaOH and the product is extracted with ether. After drying over magnesium sulfate, the solvent is removed in vacuo to afford 3,4-dihydro-5-methoxy-2H-[1]-benzothiopyran-3-amine as an oil.

Aufarbeitung

  1. customThe solvent is removed in vacuo
  2. additionthe residue is treated with 1N NaOH
  3. extractionthe product is extracted with ether
  4. dry with materialAfter drying over magnesium sulfate
  5. customthe solvent is removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-9ede53b57dd8448db98f22136220086f
Quelldatensatz
uspto-grants-1990_11
Patentnummer
US04968697

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