Methyl iodide → HCID 15086005, Verbindung

HRID 1073221Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1073221
[CH3:1][C:2]1[N:3]=[C:4]2[N:8]([C:9]=1[CH2:10][OH:11])[C:7]1[CH:12]=[CH:13][CH:14]=[CH:15][C:6]=1[S:5]2.[H-].[Na+].[CH3:18]I>CN(C)C=O>[CH3:18][O:11][CH2:10][C:9]1[N:8]2[C:4]([S:5][C:6]3[CH:15]=[CH:14][CH:13]=[CH:12][C:7]=32)=[N:3][C:2]=1[CH3:1]

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 130922Nik 228

Produkt 1

HCID 15086005HCID 15086005, VerbindungAusbeute 60,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

In 30 ml of dry dimethylformamide was suspended 2.18 g of 2-methylimidazo[2,1-b]benzothiazole-3-methanol and, 0.50 g of 60% sodium hydride was added to the suspension followed by stirring at room temperature for minutes. After 1.74 g of methyl iodide was added thereto, the mixture was stirred for one hour. Then ice water was added to the reaction mixture followed by extracting with ethyl acetate. After the ethyl acetate was removed, 1.41 g of the title compound was obtained.

Aufarbeitung

  1. additionwas added to the suspension
  2. stirringthe mixture was stirred for one hour
  3. extractionby extracting with ethyl acetate
  4. customAfter the ethyl acetate was removed

Quellen und Nachweise

ORD-Eintrag
ord-01542132dd454ae284a8761c91dbed3c
Quelldatensatz
uspto-grants-1990_11
Patentnummer
US04968708

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