(3-Butoxyphenyl)acetonitrile → HCID 22379525, Verbindung

HRID 1073242Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1073242
[CH2:1]([O:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][CH:14]=1)[CH2:9][C:10]#[N:11])[CH2:2][CH2:3][CH3:4].[H][H]>[Ni].CO>[CH2:1]([O:5][C:6]1[CH:7]=[C:8]([CH2:9][CH2:10][NH2:11])[CH:12]=[CH:13][CH:14]=1)[CH2:2][CH2:3][CH3:4]

Komponenten

5

Edukt 2

HCID 22158212(3-Butoxyphenyl)acetonitrileHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 22379525HCID 22379525, VerbindungAusbeute 106,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Raney nickel catalyst (approx 5 g) was added to a solution of 3-butyloxybenzyl cyanide (38.64 g, prepared according to example 1 D) in saturated ammoniacal methanol (700 cm3). The resulting mixture was heated at 70° C. in the presence of hydrogen (45 Atmospheres) for two hours and was then allowed to cool to room temperature overnight. The cooled mixture was filtered to remove the catalyst and was then evaporated down to give a green oil (42.2 g).

Aufarbeitung

  1. filtrationThe cooled mixture was filtered
  2. customto remove the catalyst
  3. customwas then evaporated down

Quellen und Nachweise

ORD-Eintrag
ord-7253f6f586a5486c800e761f8ff6ab2a
Quelldatensatz
uspto-grants-1990_11
Patentnummer
US04968698

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