2-(4-Methoxyphenoxy)ethylamine → 2-{2-Hydroxy-3-[2-(4-methoxyphenoxy)ethylamino]-propoxy}-5-(2-methoxyethoxy)benzonitrile

HRID 1073635Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1073635
[O:1]1[CH2:18][CH:2]1[CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][O:16][CH3:17])=[CH:9][C:6]=1[C:7]#[N:8].[CH3:19][O:20][C:21]1[CH:30]=[CH:29][C:24]([O:25][CH2:26][CH2:27][NH2:28])=[CH:23][CH:22]=1>C(O)C>[OH:1][CH:2]([CH2:18][NH:28][CH2:27][CH2:26][O:25][C:24]1[CH:29]=[CH:30][C:21]([O:20][CH3:19])=[CH:22][CH:23]=1)[CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][O:16][CH3:17])=[CH:9][C:6]=1[C:7]#[N:8]

Komponenten

4

Edukt 2

HCID 17977932-(4-Methoxyphenoxy)ethylamineHCID 13313566HCID 13313566, Verbindung

Produkt 1

HCID 133135672-{2-Hydroxy-3-[2-(4-methoxyphenoxy)ethylamino]-propoxy}-5-(2-methoxyethoxy)benzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

2.4 g of 2-(2,3-epoxypropoxy)-5-(2-methoxyethoxy)-benzonitrile and 8.35 g of 2-(4-methoxyphenoxy) ethylamine are dissolved in 30 ml of ethanol, the solvent is then evaporated and the resulting mixture stirred for 1 hour at 70°. The reaction melt is then dissolved in ether and allowed to crystallize under cooling. Purification is effected by recrystallization in benzene. The title compound is obtained (M.P. 95°-97°).

Aufarbeitung

  1. customthe solvent is then evaporated
  2. dissolutionThe reaction melt is then dissolved in ether
  3. customto crystallize
  4. temperatureunder cooling
  5. customPurification
  6. customis effected by recrystallization in benzene

Quellen und Nachweise

ORD-Eintrag
ord-bfb9ffe045f540c78de79062bc591ce1
Quelldatensatz
uspto-grants-1990_11
Patentnummer
US04970238

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