Hexane → 1-(4-Chlorophenyl)-2-cyclopropylpropan-1-one

HRID 1074318Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1074318
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:14])[CH:9]([CH:11]2[CH2:13][CH2:12]2)[CH3:10])=[CH:4][CH:3]=1.C(N(CC)CC)C.CCCCCC>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:14])[CH:9]([CH:11]2[CH2:13][CH2:12]2)[CH3:10])=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 8058HexaneHCID 8471TriethylamineHCID 190783851-(4-Chlorophenyl)-2-cyclopropylpropan-1-ol

Produkt 1

HCID 134886191-(4-Chlorophenyl)-2-cyclopropylpropan-1-oneAusbeute 86 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

After 15 minutes 1-(4-chlorophenyl)-2-cyclopropylpropan-1-ol (44.72 g, 212 mmol) in dry dichloromethane (330 ml) was added over approximately 35 minutes. After 75 minutes triethylamine (154 ml), 1105 mmol) was added and the mixture allowed to warm to room temperature. Hexane was added and the mixture washed with 1M hydrochloric acid, saturated aqueous sodium bicarbonate solution and water, dried and evaporated in vacuo. Chromatography [SiO2, hexane-ethyl acetate (100:0) to (90:10)] gave 1-(4-chlorophenyl)-2-cyclopropylpropan-1-one (38.0 g, 86%).

Aufarbeitung

  1. washthe mixture washed with 1M hydrochloric acid, saturated aqueous sodium bicarbonate solution and water
  2. customdried
  3. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-c83872dbc42b4e8ab42ab55217af0e02
Quelldatensatz
uspto-grants-1990_11
Patentnummer
US04973767

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