Tert-Butylamine → HCID 13178322, Verbindung

HRID 1074371

Reaktionsgleichung

Reaktionsgleichung von HRID 1074371
[C:1]([NH2:5])([CH3:4])([CH3:3])[CH3:2].[S:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8]([S:15](Cl)(=[O:17])=[O:16])=[CH:7]1>O1CCCC1>[C:1]([NH:5][S:15]([C:8]1[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[S:6][CH:7]=1)(=[O:16])=[O:17])([CH3:4])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 6385Tert-ButylamineHCID 27763401-Benzothiophene-3-sulfonyl chloride

Produkt 1

HCID 13178322HCID 13178322, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To 25 g of tert-butyl amine in 100 ml of dry tetrahydrofuran was added dropwise with cooling 34 g of benzothiophene-3-sulfonyl chloride. The reaction mixture was allowed to come to room temperature and then poured into 200 g of ice. The phases were separated and the organic portion was washed with water, dried over magnesium sulfate and evaporated in vacuo. The residue thus obtained melted at 146°-148° after recrystallization from alcohol. It showed an absorption peak by NMR at 1.34 δ (singlet), for tert-butyl and 7.4-8.4 δ (multiplet) for benzothiophene consistent for the desired product.

Aufarbeitung

  1. customto come to room temperature
  2. customThe phases were separated
  3. washthe organic portion was washed with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated in vacuo
  6. customThe residue thus obtained melted at 146°-148° after recrystallization from alcohol

Quellen und Nachweise

ORD-Eintrag
ord-c5dc0a21952943dbae1a78ce65def847
Quelldatensatz
uspto-grants-1983_07
Patentnummer
US04391627

Verknüpfte Notizen

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