Hydrochloric Acid → Methyl 3-sulfamoyl-1-benzothiophene-2-carboxylate

HRID 1074373Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1074373
C([NH:5][S:6]([C:9]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[S:11][C:10]=1[C:18]([O-:20])=[O:19])(=[O:8])=[O:7])(C)(C)C.Cl.[CH3:22]O>>[NH2:5][S:6]([C:9]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[S:11][C:10]=1[C:18]([O:20][CH3:22])=[O:19])(=[O:8])=[O:7]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 867389413-Tert-butylaminosulfonylbenzothiophene-2-carboxylate

Produkt 1

HCID 13178321Methyl 3-sulfamoyl-1-benzothiophene-2-carboxylate

Versuchsvorschrift

A solution of 6 g of 3-tert-butylaminosulfonylbenzothiophene-2-carboxylate acid in 100 ml of methanol was saturated with anhydrous hydrogen chloride and then heated to reflux for three hours. The mixture was evaporated in vacuo to half of its volume and the residue poured into 200 g of ice and filtered to yield the desired product melting at 150°-154°. The infrared absorption spectrum shown by this material was qualitatively equivalent to that of the product of Example 4.

Aufarbeitung

  1. temperatureheated
  2. temperatureto reflux for three hours
  3. customThe mixture was evaporated in vacuo to half of its volume
  4. additionthe residue poured into 200 g of ice
  5. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-e853363dd4d946f4908ab3b7e0dc3837
Quelldatensatz
uspto-grants-1983_07
Patentnummer
US04391627

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