Piperidine → HCID 20496598, Verbindung

HRID 1074389Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1074389
Cl[C:2]1[CH:14]=[CH:13][C:5]2=[N:6][C:7]3[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=3[N:4]2[N:3]=1.[NH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>>[N:15]1([C:2]2[CH:14]=[CH:13][C:5]3=[N:6][C:7]4[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=4[N:4]3[N:3]=2)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

Komponenten

3

Edukt 2

HCID 8082PiperidineHCID 11148455HCID 11148455, Verbindung

Produkt 1

HCID 20496598HCID 20496598, Verbindung

Versuchsvorschrift

A solution of 5.0 g of 2-chloro-6,7,8,9-tetrahydropyridazino[1,6-a]benzimidazole in 30 ml of piperidine was stirred and heated at reflux for 72 hours. The reaction mixture was poured into 200 ml of ice water and the tan solid which formed was separated by filtration and air dried. It was then recrystallized from a mixture of ethanol and water to give 2-(1-piperidinyl)-6,7,8,9-tetrahydropyridazino[1,6-a]benzimidazole melting at about 184°-185° C.

Aufarbeitung

  1. temperatureheated
  2. temperatureat reflux for 72 hours
  3. customthe tan solid which formed
  4. customwas separated by filtration and air
  5. customdried
  6. customIt was then recrystallized from a mixture of ethanol and water

Quellen und Nachweise

ORD-Eintrag
ord-85e88e01e10f4ea59afe1e3eb82b2c5d
Quelldatensatz
uspto-grants-1983_07
Patentnummer
US04391806

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