Sodium Hydroxide → Pentiapine

HRID 1074408

Reaktionsgleichung

Reaktionsgleichung von HRID 1074408
[C:1]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[N:13]3[CH:25]=[CH:24][N:23]=[C:14]3[S:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[N:18]=2)[CH2:8][CH2:7]1)(OCC)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>O1CCCC1>[CH3:1][N:6]1[CH2:11][CH2:10][N:9]([C:12]2[N:13]3[CH:25]=[CH:24][N:23]=[C:14]3[S:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[N:18]=2)[CH2:8][CH2:7]1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 131782745-(4-Carboethoxypiperazino)-imidazo[2,1-b][1,3,5]benzothiadiazepineHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 54742Pentiapine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To the solution of 0.2 g of 5-(4-carboethoxypiperazino)-imidazo[2,1-b][1,3,5]benzothiadiazepine in 2 ml of dry tetrahydrofuran, 100 mg of lithium aluminum hydride are added at once and the mixture is refluxed under nitrogen for 48 hrs. The mixture is cooled to room temperature, stirred with 0.2 ml of 30% sodium hydroxide, and filtered. The filtrates were evaporated to dryness and the product is purified to give 5-(4-methylpiperazino)-imidazo[2,1-b][1,3,5]benzothiadiazepine, melting at 145°-7°, and identical to compound obtained in example 1.

Aufarbeitung

  1. temperatureis refluxed under nitrogen for 48 hrs
  2. filtrationfiltered
  3. customThe filtrates were evaporated to dryness
  4. customthe product is purified

Quellen und Nachweise

ORD-Eintrag
ord-673815c62fd1473286d49b5721daa2ad
Quelldatensatz
uspto-grants-1983_07
Patentnummer
US04391808

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