1,1-Diphenylacetone → 3-Diphenylmethyl-2,3,6,7,-tetrahydro-5H-thiazolo[3,2-a]pyrimidin-3-ol hydrobromide

HRID 1074534

Reaktionsgleichung

Reaktionsgleichung von HRID 1074534
[C:1]1([CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8](=[O:10])[CH3:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:17]CC(=O)C(C1C=CC=CC=1)C1C=CC=CC=1.[NH:34]1[CH2:39][CH2:38][CH2:37][NH:36][C:35]1=[S:40]>CC(C)=O>[BrH:17].[C:11]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8]2([OH:10])[N:36]3[CH2:37][CH2:38][CH2:39][N:34]=[C:35]3[S:40][CH2:9]2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Komponenten

5

Edukt 3

HCID 699071,1-DiphenylacetoneHCID 2723785Tetrahydropyrimidine-2-thioneHCID 27946353-Bromo-1,1-diphenylacetone2×

Produkt 1

HCID 204957133-Diphenylmethyl-2,3,6,7,-tetrahydro-5H-thiazolo[3,2-a]pyrimidin-3-ol hydrobromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel2×

Versuchsvorschrift

A 2.1 g. portion of 1,1-diphenyl-2-propanone is converted to 1-bromo-3,3-diphenyl-2-propanone by the procedure of Example 22. The 1-bromo-3,3-diphenyl-2-propanone is dissolved in 15 ml. of acetone and added to a boiling mixture of 0.80 g. of tetrahydro-2-pyrimidinethione in 70 ml. of acetone. This mixture is allowed to stand for 48 hours and the resulting solid is collected by filtration, giving the desired product, m.p. 196°-198° C.

Aufarbeitung

  1. filtrationthe resulting solid is collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-efa704cb1c0d421ba273e5a225d15ade
Quelldatensatz
uspto-grants-1983_07
Patentnummer
US04393004

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