1H-1,2,4-Triazole → 1-(1-Butoxyethyl)-1H-1,2,4-triazole

HRID 1074890Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1074890
Cl[CH:2]([O:4][CH2:5][CH2:6][CH2:7][CH3:8])[CH3:3].[NH:9]1[CH:13]=[N:12][CH:11]=[N:10]1>C(#N)C>[N:9]1([CH:2]([O:4][CH2:5][CH2:6][CH2:7][CH3:8])[CH3:3])[CH:13]=[N:12][CH:11]=[N:10]1

Komponenten

4

Edukt 2

HCID 92571H-1,2,4-TriazoleHCID 12617703HCID 12617703, Verbindung

Produkt 1

HCID 126262961-(1-Butoxyethyl)-1H-1,2,4-triazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Crude n-butyl 1-chloroethyl ether (Straus and Weber, Ann, 1932, 498, 124) was treated with 1,2,4-triazole (2.4 g) in acetonitrile (50 ml) to give at once a precipitate. The mixture was refluxed for 2 hours. The solvent was removed under reduced pressure. The residue was treated with water and extracted with diethyl ether. The ethereal layer was washed with water and dried over magnesium sulphate, and the solvent was removed to give the title product as a colourless oil, which was shown by GLC to be 95% pure.

Aufarbeitung

  1. customto give at once a precipitate
  2. temperatureThe mixture was refluxed for 2 hours
  3. customThe solvent was removed under reduced pressure
  4. additionThe residue was treated with water
  5. extractionextracted with diethyl ether
  6. washThe ethereal layer was washed with water
  7. dry with materialdried over magnesium sulphate
  8. customthe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-06395c26ada94d9997f77c5a4f844b68
Quelldatensatz
uspto-grants-1983_07
Patentnummer
US04394380

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