Allyl bromide → HCID 178460812, Verbindung
Reaktionsgleichung
[CH2:1](Br)[CH:2]=[CH2:3].[F:5][C:6]1[C:7](=[S:13])[NH:8][C:9](=[O:12])[NH:10][CH:11]=1.[OH-].[Na+]>>[CH2:1]([S:13][C:7]1[C:6]([F:5])=[CH:11][NH:10][C:9](=[O:12])[N:8]=1)[CH:2]=[CH2:3]Komponenten
4
Versuchsvorschrift
Allyl bromide (0.013 mol) was added to a solution of 5-fluoro-4-thiouracil (0.01 mols), 8.73 mols NaOH (25 mls) and the reaction mixture stirred at room temperature for 5 hrs. The reaction mixture was then extracted with chloroform (2×5 ml), before the aqueous solution was acidified with HCl when the titled compound was precipitated; yield 40%, m.p. 150°-152° C. (water). (Found: C, 44.87; H, 3.84. Calc. for C7H7SFN2O; C, 45.15; H, 3.80).
Aufarbeitung
- extractionThe reaction mixture was then extracted with chloroform (2×5 ml), before the aqueous solution
- customwas precipitated
Quellen und Nachweise
- ORD-Eintrag
- ord-011ba0ee29b7445090fda7826c7619c3
- Quelldatensatz
- uspto-grants-1983_07
- Patentnummer
- US04395406
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