Hydrochloric Acid → 2-(6-Formamidopyridin-2-yl)-2-propoxyiminoacetic acid

HRID 1075261Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1075261
C(NC1N=C(C(=O)C(SC)=O)C=CC=1)=O.[OH-].[Na+].[CH:18]([NH:20][C:21]1[N:26]=[C:25]([C:27](=O)[C:28]([OH:30])=[O:29])[CH:24]=[CH:23][CH:22]=1)=[O:19].Cl.[CH2:33]([O:36][NH2:37])[CH2:34][CH3:35].Cl>CO>[CH:18]([NH:20][C:21]1[N:26]=[C:25]([C:27](=[N:37][O:36][CH2:33][CH2:34][CH3:35])[C:28]([OH:30])=[O:29])[CH:24]=[CH:23][CH:22]=1)=[O:19]

Komponenten

7

Edukt 5

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12283955O-propylhydroxylamine hydrochlorideHCID 13060226S-methyl 2-(6-formamidopyridin-2-yl)thioglyoxylateHCID 197901652-(6-Formamidopyridin-2-yl)glyoxylic acid

Produkt 1

HCID 536647912-(6-Formamidopyridin-2-yl)-2-propoxyiminoacetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

(4)-(a) A mixture of S-methyl 2-(6-formamidopyridin-2-yl)thioglyoxylate (4.48 g.), methanol (20 ml.) and 1 N aqueous solution of sodium hydroxide (20 ml.) was stirred for 50 minutes at ambient temperature to give a solution containing 2-(6-formamidopyridin-2-yl)glyoxylic acid. To the solution was added O-propylhydroxylamine hydrochloride (2.23 g.), and the mixture was stirred for 35 minutes at the same temperature. The reaction mixture was adjusted to pH 7 with hydrochloric acid and the methanol was distilled off. The remaining aqueous mixture was washed with ethyl acetate, and ethyl acetate was added thereto and then adjusted to pH 1 with 10% hydrochloric acid. The ethyl acetate layer was separated, washed with water, dried over magnesium sulfate, treated with activated charcoal and then the solvent was distilled off. Thus obtained product was washed with a mixture of diethyl ether and diisopropyl ether and then dried to give 2-(6-formamidopyridin-2-yl)-2-propoxyiminoacetic acid (syn isomer) (1.76 g.), mp. 140° to 142° C. (dec.).

Aufarbeitung

  1. customto give a solution
  2. stirringthe mixture was stirred for 35 minutes at the same temperature
  3. distillationthe methanol was distilled off
  4. washThe remaining aqueous mixture was washed with ethyl acetate, and ethyl acetate
  5. additionwas added
  6. customThe ethyl acetate layer was separated
  7. washwashed with water
  8. dry with materialdried over magnesium sulfate
  9. additiontreated with activated charcoal
  10. distillationthe solvent was distilled off
  11. washThus obtained product was washed with a mixture of diethyl ether and diisopropyl ether
  12. customdried

Quellen und Nachweise

ORD-Eintrag
ord-64058680b9de48c98e8672756b7788ff
Quelldatensatz
uspto-grants-1983_07
Patentnummer
US04395411

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