Dimethylformamide dimethyl acetal → 2-(6-Chloro-3-nitropyridin-2-yl)-N,N-dimethylethen-1-amine

HRID 1075562Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1075562
[Cl:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][CH:3]=1.CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>CN(C)C=O.C(N(CC)CC)C>[CH3:14][N:15]([CH3:17])[CH:16]=[CH:8][C:6]1[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][CH:3]=[C:2]([Cl:1])[N:7]=1

Komponenten

5

Edukt 2

HCID 78373Dimethylformamide dimethyl acetal2×HCID 2531236-Chloro-2-methyl-3-nitropyridine

Produkt 1

HCID 537327152-(6-Chloro-3-nitropyridin-2-yl)-N,N-dimethylethen-1-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8471TriethylamineKatalysatorHCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A solution of 5 gm (29 mMol) 6-chloro-3-nitro-2-picoline in 40 mL dimethylformamide was treated with 5.83 mL (44 mMol) dimethylformamide dimethylacetal and the resulting mixture heated at 100° C. for 1.5 hours. At this point, 2 drops of triethylamine followed by 1.9 mL dimethylformamide dimethylacetal were added and heating continued for 2 more hours. The reaction mixture was concentrated under reduced pressure to provide the desired compound.

Aufarbeitung

  1. additionwere added
  2. temperatureheating
  3. concentrationThe reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1ebd330245274c77818e033abdec12bd
Quelldatensatz
uspto-grants-1999_05
Patentnummer
US05905084

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