Dimethyl Sulfate → alpha-Methoxymethylene-beta-formylaminopropionitrile

HRID 1075779Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1075779
[Na][C:2]([CH:4]([CH2:7][NH:8][CH:9]=[O:10])[C:5]#[N:6])=[O:3].S(OC)(O[CH3:15])(=O)=O>O1CCCC1>[CH3:15][O:3][CH:2]=[C:4]([CH2:7][NH:8][CH:9]=[O:10])[C:5]#[N:6]

Komponenten

4

Edukt 2

HCID 6497Dimethyl SulfateHCID 178511136HCID 178511136, Verbindung

Produkt 1

HCID 54062148alpha-Methoxymethylene-beta-formylaminopropionitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

To the residue of α-sodioformyl-β-formylaminopropionitrile is added 300 parts by volume of tetrahydrofuran and 138 parts of dimethyl sulfate. The mixture is reacted under stirring at 70°C for 5 hours. After completion of the reaction, the mixture is cooled at 25°C. The precipitated sodium methyl sulfate is removed and the filtrate is concentrated and kept standing overnight, whereby 135 parts of α-methoxymethylene-β-formylaminopropionitrile is obtained as crystals.

Aufarbeitung

  1. customThe mixture is reacted
  2. customAfter completion of the reaction
  3. temperaturethe mixture is cooled at 25°C
  4. customThe precipitated sodium methyl sulfate is removed
  5. concentrationthe filtrate is concentrated
  6. waitkept standing overnight

Quellen und Nachweise

ORD-Eintrag
ord-fea30e1414974331ab478085dd5b042e
Quelldatensatz
uspto-grants-1976_05
Patentnummer
US03954756

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