Reaktionsgleichung
[C:1]([NH2:5])(=[NH:4])[CH2:2][CH3:3].CO[CH:8]=[C:9]([CH2:12][NH:13][CH:14]=[O:15])[C:10]#[N:11]>C(O)C>[CH2:2]([C:1]1[N:5]=[C:10]([NH2:11])[C:9]([CH2:12][NH:13][CH:14]=[O:15])=[CH:8][N:4]=1)[CH3:3]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 25 °C
Versuchsvorschrift
In 50 parts by volume of ethanol is dissolved 14 parts of α-methoxymethylene-β-formylaminopropionitrile. To the solution is added 100 parts by volume of an ethanol solution containing 17 parts of propioamidine. The mixture is reacted at 30°C for 0.5 hour. After the reaction, ethanol is distilled off and the residue is cooled at 25°C, whereby 18 parts of 2-ethyl-4-amino-5-formylaminomethylpyrimidine is obtained as crystals. (Yield: 100 %). Recrystallization of the crystals from benzene-ethanol mixture gives colorless crystals melting at 185°C.
Aufarbeitung
- customThe mixture is reacted at 30°C for 0.5 hour
- distillationis distilled off
Quellen und Nachweise
- ORD-Eintrag
- ord-a84e57b730254675a6ed4814c194a5b9
- Quelldatensatz
- uspto-grants-1976_05
- Patentnummer
- US03954756
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