Formamide → 7-Methyl-2,3-dihydroisoquinolin-3-one

HRID 1075821

Reaktionsgleichung

[CH:1]([NH:3][C:4](=[O:13])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][CH:7]=1)=O.C(N)=O.CC1C=CC(CC(Cl)=O)=CC=1.C(N(C)C(=O)CC1C=CC=CC=1)=O>>[CH3:12][C:9]1[CH:8]=[CH:7][C:6]2[C:11]([CH:10]=1)=[CH:1][NH:3][C:4](=[O:13])[CH:5]=2

Komponenten

Edukt 4

HCID 713Formamide

HCID 27606342-(4-Methylphenyl)acetyl chloride

HCID 21541248N-formyl-2-(p-methylphenyl)-acetamide

HCID 21541252N-formyl-N-methyl-2-phenyl-acetamide

Produkt 1

HCID 215412587-Methyl-2,3-dihydroisoquinolin-3-one

Versuchsvorschrift

The N-formyl-2-(p-methylphenyl)-acetamide (m.p. 144°-146°C.) used as starting material was prepared from formamide and 4-methyl-phenyl-acetyl chloride in the manner described in Example 2 for the preparation of N-formyl-N-methyl-2-phenyl-acetamide.

Quellen und Nachweise

ORD-Eintrag: ord-93e36159cab04c1d972f97e0de8a5795
Quelldatensatz: uspto-grants-1976_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US03954771

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