3-Methylbenzoic acid → Methoxyphenone

HRID 1076081Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1076081
[C:1]1([CH3:10])[CH:6]=[CH:5][CH:4]=[C:3]([C:7](O)=[O:8])[CH:2]=1.[CH3:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH3:19]>>[CH3:19][O:18][C:13]1[CH:14]=[CH:15][C:16]([C:7]([C:3]2[CH:4]=[CH:5][CH:6]=[C:1]([CH3:10])[CH:2]=2)=[O:8])=[CH:17][C:12]=1[CH3:11]

Komponenten

3

Edukt 2

HCID 74183-Methylbenzoic acidHCID 336372-Methylanisole

Produkt 1

HCID 38839MethoxyphenoneAusbeute 60 %

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

m-Toluic acid (13.6 g, 0.10 mole) and o-methylanisole (12.2 g, 0.10 mole) are combined in 50 ml of polyphosphoric acid (PPA) and warmed with stirring to 80°C for 2 hours. The cooled reaction mixture is then poured into ice water and extracted into ethyl acetate (200 ml) and washed with 5% sodium hydroxide to give 14.4 g of product (60%), m.p. 62°-4°C, upon removal of the solvent in vacuo.

Aufarbeitung

  1. temperaturewarmed
  2. customThe cooled reaction mixture
  3. extractionextracted into ethyl acetate (200 ml)
  4. washwashed with 5% sodium hydroxide

Quellen und Nachweise

ORD-Eintrag
ord-6f289b6b8dab49d5b6d8ad7a188fbfa0
Quelldatensatz
uspto-grants-1976_05
Patentnummer
US03954875

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