Ethyl glycylglycinate → N-{N-[2-(p-chlorophenoxy)-2-methylpropionyl]glycyl}glycine ethyl ester

HRID 1076349

Reaktionsgleichung

Reaktionsgleichung von HRID 1076349
[CH2:1]([O:3][C:4](=[O:11])[CH2:5][NH:6][C:7](=[O:10])[CH2:8][NH2:9])[CH3:2].C1(=O)N([O:17][C:18](=O)[C:19]([O:22][C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=2)([CH3:21])[CH3:20])C(=O)CC1>>[CH2:1]([O:3][C:4](=[O:11])[CH2:5][NH:6][C:7](=[O:10])[CH2:8][NH:9][C:18](=[O:17])[C:19]([O:22][C:23]1[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=1)([CH3:21])[CH3:20])[CH3:2]

Komponenten

3

Edukt 2

HCID 124706Ethyl glycylglycinateHCID 858109502,5-Dioxopyrrolidin-1-yl 2-(4-chlorophenoxy)-2-methylpropanoate

Produkt 1

HCID 21426057N-{N-[2-(p-chlorophenoxy)-2-methylpropionyl]glycyl}glycine ethyl ester

Versuchsvorschrift

Likewise, by following the procedure of Example 1 but replacing proline methyl ester hydrochloride with glycylglycine ethyl ester and replacing the "activated ester" N-{N-[2-(p-chlorophenoxy)-2-methylpropionyl]glycine} succinimido ester with an equivalent amount of the "activated ester", 2-(p-chlorophenoxy)-2-methyl-propionic acid succinimido ester, obtained in an analogous manner as the aforementioned "activated ester", N-{N-[2-(p-chlorophenoxy)-2-methylpropionyl]glycyl}glycine ethyl ester again is obtained.

Quellen und Nachweise

ORD-Eintrag
ord-3bdb08b3e4ee41b3a8453ac327b60bf6
Quelldatensatz
uspto-grants-1976_05
Patentnummer
US03956484

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