Sodium Carbonate → 2-[3-Bis(2-hydroxyethyl)aminopropyl]amino-quinoline

HRID 1076640

Reaktionsgleichung

Reaktionsgleichung von HRID 1076640
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[OH:12][CH2:13][CH2:14][N:15]([CH2:19][CH2:20][CH2:21][NH2:22])[CH2:16][CH2:17][OH:18].C(=O)([O-])[O-].[Na+].[Na+]>C(O)(C)C>[OH:18][CH2:17][CH2:16][N:15]([CH2:14][CH2:13][OH:12])[CH2:19][CH2:20][CH2:21][NH:22][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Komponenten

5

Edukt 3

HCID 10340Sodium CarbonateHCID 119282-ChloroquinolineHCID 21088(3-Aminopropyl)diethanolamine

Produkt 1

HCID 214246762-[3-Bis(2-hydroxyethyl)aminopropyl]amino-quinoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

A mixture of 5.05 g. of 2-chloroquinoline, 5.5 g. of bis(2-hydroxyethyl)aminopropylamine and 3.0 g. of sodium carbonate is heated in 20 ml. of refluxing isopropanol for 24 hours. The reaction mixture is then filtered, solvent removed in vacuo and the residue chromatographed over silica gel to obtain an oil of 2-[3-bis(2-hydroxyethyl)aminopropyl]amino-quinoline.

Aufarbeitung

  1. additionA mixture of 5.05 g
  2. filtrationThe reaction mixture is then filtered
  3. customsolvent removed in vacuo
  4. customthe residue chromatographed over silica gel

Quellen und Nachweise

ORD-Eintrag
ord-4cba11c84e484caf92dbc30029cbe211
Quelldatensatz
uspto-grants-1976_05
Patentnummer
US03957791

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