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Thionyl Chloride → Bis(3-di-n-butylaminopropyl)xanthene-2,7-dicarboxylate dihydrochloride

HRID 1076823
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1076823
[CH:1]1[C:14]2[CH2:13][C:12]3[C:7](=[CH:8][CH:9]=[C:10]([C:15]([OH:17])=[O:16])[CH:11]=3)[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[C:18]([OH:20])=[O:19].S(Cl)([Cl:23])=O.[CH2:25]([N:29]([CH2:34][CH2:35][CH2:36][CH3:37])[CH2:30][CH2:31][CH2:32]O)[CH2:26][CH2:27][CH3:28]>N1C=CC=CC=1.C1C=CC=CC=1.C(Cl)Cl>[ClH:23].[ClH:23].[CH2:25]([N:29]([CH2:34][CH2:35][CH2:36][CH3:37])[CH2:30][CH2:31][CH2:32][O:16][C:15]([C:10]1[CH:9]=[CH:8][C:7]2[O:6][C:5]3[C:14](=[CH:1][C:2]([C:18]([O:20][CH2:32][CH2:31][CH2:30][N:29]([CH2:34][CH2:35][CH2:36][CH3:37])[CH2:25][CH2:26][CH2:27][CH3:28])=[O:19])=[CH:3][CH:4]=3)[CH2:13][C:12]=2[CH:11]=1)=[O:17])[CH2:26][CH2:27][CH3:28]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 3

HCID 24386Thionyl ChlorideHCID 749051-Propanol, 3-(dibutylamino)-HCID 12340268Xanthene-2,7-dicarboxylic acid

Produkt 1

HCID 12340270Bis(3-di-n-butylaminopropyl)xanthene-2,7-dicarboxylate dihydrochlorideAusbeute 31,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1049PyridineKatalysator
HCID 23443464
Methane, dichloro-, compd. with benzene (1:1)
Lösungsmittel

Versuchsvorschrift

To 17.4 g (0.06 mole) of xanthene-2,7-dicarboxylic acid was added 100 ml (1.4 moles) of thionyl chloride and 4 drops of pyridine. The resulting solution was refluxed for four hours and solvent and excess thionyl chloride were removed. The intermediate diacid chloride in benzene-methylene chloride was reacted with 24 g (0.13 mole) of 3-di-n-butylamino-1-propanol by refluxing for three hours. Most of the solvent was removed and the residue allowed to stand for two days. The residue was diluted with methylene chloride and 10% hydrochloric acid. The organic layer and two methylene chloride washings of the aqueous layer were combined and dried over anhydrous magnesium sulfate. The solution was filtered and concentrated at reduced pressure to a solid residue. This was purified from isopropanol to give 12.9 g (29.6%) of bis(3-di-n-butylaminopropyl)xanthene-2,7-dicarboxylate dihydrochloride. M.P. 187.5°-190°C.

Aufarbeitung

  1. temperatureThe resulting solution was refluxed for four hours
  2. customsolvent and excess thionyl chloride were removed
  3. temperatureby refluxing for three hours
  4. customMost of the solvent was removed
  5. additionThe residue was diluted with methylene chloride and 10% hydrochloric acid
  6. dry with materialdried over anhydrous magnesium sulfate
  7. filtrationThe solution was filtered
  8. concentrationconcentrated at reduced pressure to a solid residue
  9. customThis was purified from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-2321398eeec549dd8a23dc6f9b73b3d4
Quelldatensatz
uspto-grants-1976_05
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US03957986

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