HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4,6-Dimethoxypyrimidine-5-carbaldehyde → 2,6-Diamino-4-(4,6-dimethoxypyrimid-5-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4,6-Dimethoxypyrimidine-5-carbaldehyde | HCID 4436645 | — |
| Edukt | Carbamimidoyl-acetic acid ethyl ester | HCID 4599837 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 2,6-Diamino-4-(4,6-dimethoxypyrimid-5-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 70631685 | 56% |
Reaktionsschritte
Upon heating a solution of 8.4 g 4,6-dimethoxypyrimidine-5-aldehyde and 13.0 g amidinoacetic acid ethyl ester in 150 ml ethanol for 2 hours, 2,6-diamino-4-(4,6-dimethoxypyrimid-5-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester of m.p. 219°C (ethanol) is obtained. Yield: 56% of theory.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US03957998 |
| Quelldatensatz | uspto-grants-1976_05 |
| ORD ID | ord-ba5fbac887b946e98c07d57fc066d96f |
| Quellennotiz | uspto-grants-1976_05 |