21-Bromo-5alpha-pregnane-3,11,20-trione → 21-Morpholinoacetylthio-5alpha-pregnane-3,11,20-trione

HRID 1077024Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1077024
Br[CH2:2][C:3](=[O:25])[C@@H:4]1[C@:21]2([CH3:22])[C@H:7]([C@H:8]3[C@H:18]([C:19](=[O:23])[CH2:20]2)[C@:16]2([CH3:17])[C@H:11]([CH2:12][C:13](=[O:24])[CH2:14][CH2:15]2)[CH2:10][CH2:9]3)[CH2:6][CH2:5]1.[O:26]1[CH2:31][CH2:30][N:29]([CH2:32][C:33]([OH:35])=[S:34])[CH2:28][CH2:27]1>CC(C)=O>[O:26]1[CH2:31][CH2:30][N:29]([CH2:32][C:33]([S:34][CH2:2][C:3](=[O:25])[C@@H:4]2[C@:21]3([CH3:22])[C@H:7]([C@H:8]4[C@H:18]([C:19](=[O:23])[CH2:20]3)[C@:16]3([CH3:17])[C@H:11]([CH2:12][C:13](=[O:24])[CH2:14][CH2:15]3)[CH2:10][CH2:9]4)[CH2:6][CH2:5]2)=[O:35])[CH2:28][CH2:27]1

Komponenten

4

Edukt 2

HCID 8673347421-Bromo-5alpha-pregnane-3,11,20-trioneHCID 178526202HCID 178526202, Verbindung

Produkt 1

HCID 8673347521-Morpholinoacetylthio-5alpha-pregnane-3,11,20-trione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

21-Bromo-5α-pregnane-3,11,20-trione (1.04 g.) was refluxed in dry acetone (100 ml) with morpholino thioacetic acid (600 mg) for 15 minutes. The reaction mixture was concentrated, partitioned between ethyl acetate, water, pH 8, the organic layer was washed, dried (MgSO4) and evaporated to an off white solid (1.26g.)

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. custompartitioned between ethyl acetate, water, pH 8
  3. washthe organic layer was washed
  4. dry with materialdried (MgSO4)
  5. customevaporated to an off white solid (1.26g.)

Quellen und Nachweise

ORD-Eintrag
ord-01fbc72acd6a4967b3bcd2a3737a6870
Quelldatensatz
uspto-grants-1976_05
Patentnummer
US03959260

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