4-Chlorobutyryl chloride → 3-(gamma-Chlorobutyramido)-1-butyne

Beteiligte Stoffe

Reaktionsschritte

The compound 3-amino-1-butyne was treated with γ-chlorobutyryl chloride giving 3-(γ-chlorobutyramido)-1-butyne, m.p. 50°-51°C., which was ring-closed to N-(1-methylpropargyl)-pyrrolidin-2-one with the boiling point 71°C. at 0.8 mm Hg. Treatment of this product with formaldehyde and pyrrolidine yielded a reaction product which was isolated and purified as the sesquioxalate. It melted at 117°-119°C. after recrystallization from ethanol-ether.

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