HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ethyl benzylidenecyanoacetate → 2,6-Diamino-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester 5-isopropyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ethyl benzylidenecyanoacetate | HCID 74845 | — |
| Edukt | Sodium ethoxide | HCID 2723922 | — |
| Edukt | Amidinoacetic acid isopropyl ester | HCID 12391080 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 2,6-Diamino-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester 5-isopropyl ester | HCID 70631841 | 54% |
Reaktionsschritte
Upon heating a solution of 10.1 g benzylidenecyanoacetic acid ethyl ester, 7.2 g amidinoacetic acid isopropyl ester and 0.6 g sodium ethylate in 150 ml ethanol for four hours, 2,6-diamino-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester 5-isopropyl ester of m.p. 170° is obtained.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US03959474 |
| Quelldatensatz | uspto-grants-1976_05 |
| ORD ID | ord-25c43c571116497abed3e41dcccb9ec9 |
| Quellennotiz | uspto-grants-1976_05 |