Ethyl 2-methylacetoacetate → 5,6-dimethyl-2-(4-methylphenyl)-3H-pyrimidin-4-one

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a solution of 4-methylbenzamidine (4.4 g) in 30 ml of ethanol was added ethyl 2-methylacetoacetate (6.1 g), and the mixture refluxed for 4 hours, giving a precipitate. The mixture was cooled to 0° C., the solid filtered off, washed with ethanol, and dried under reduced pressure, yielding 6 g of 5,6-dimethyl-2-(4-methylphenyl)-3H-pyrimidin-4-one, m.p. 250° C.

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