Trifluoroacetic acid → (Piperidin-4-yloxy)acetic acid methyl ester hydrochloride

HRID 1077911Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1077911
F[C:2](F)(F)C([O-])=O.[NH:8]1[CH2:13][CH2:12][CH:11]([O:14][CH2:15][C:16]([OH:18])=[O:17])[CH2:10][CH2:9]1.FC(F)(F)C(O)=O.S(Cl)([Cl:28])=O>ClCCl.CO>[ClH:28].[NH:8]1[CH2:9][CH2:10][CH:11]([O:14][CH2:15][C:16]([O:18][CH3:2])=[O:17])[CH2:12][CH2:13]1

Komponenten

7

Edukt 4

HCID 6422Trifluoroacetic acidHCID 24386Thionyl ChlorideHCID 84468TrifluoroacetateHCID 184236272-(Piperidin-4-yloxy)acetic acid

Produkt 1

HCID 21835549(Piperidin-4-yloxy)acetic acid methyl ester hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

By esterifying the trifluoroacetate of 4-piperidinyloxy-acetic acid (prepared by treating the product of Example 1c) with trifluoroacetic acid in dichloromethane) in methanol in the presence of thionyl chloride there is obtained methyl 4-piperidinyloxyacetate hydrochloride, MS (EI): 173 (M)+.

Aufarbeitung

  1. customprepared

Quellen und Nachweise

ORD-Eintrag
ord-49b97071c3424f3b9a76909d0eae833d
Quelldatensatz
uspto-grants-1996_08
Patentnummer
US05545658

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