Hydrochloric Acid → HCID 86749750, Verbindung

HRID 1078718Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1078718
C(OC([N:8]1[CH2:12][C@H:11]([O:13][Si](C(C)(C)C)(C)C)[CH2:10][C@H:9]1[C:21](=[O:27])[CH2:22][C:23](=[O:26])[NH:24][CH3:25])=O)(C)(C)C.[ClH:28]>CO>[ClH:28].[OH:13][C@H:11]1[CH2:12][NH:8][C@H:9]([C:21](=[O:27])[CH2:22][C:23](=[O:26])[NH:24][CH3:25])[CH2:10]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 22865011HCID 22865011, Verbindung

Produkt 1

HCID 86749750HCID 86749750, VerbindungAusbeute 62 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

To a solution of (2S,4R)-N-tert-butoxycarbonyl-4-tert-butyldimethylsiloxy-2-[2-(N-methylcarbamoyl)-1-oxoethyl]pyrrolidine (2.07 g, 5.3 mmol) in methanol (10 ml) was added a 5.5N hydrogen chloride--methanol solution (6 ml, 33 mmol). The mixture was stirred at room temperature for 6 h. The reaction solution was concentrated in vacuo. Tetrahydrofuran and ethanol were added to the obtained residue, and the precipitate was collected by filtration and washed with ethanol to obtain (2S,4R)-4-hydroxy-2-[2-(N-methylcarbamoyl)-1-oxoethyl]pyrrolidine monohydrochloride (737 mg, yield: 62%).

Aufarbeitung

  1. concentrationThe reaction solution was concentrated in vacuo
  2. additionTetrahydrofuran and ethanol were added to the obtained residue
  3. filtrationthe precipitate was collected by filtration
  4. washwashed with ethanol

Quellen und Nachweise

ORD-Eintrag
ord-67a4d905d8a94c0ea3c6fe07db6b2ca8
Quelldatensatz
uspto-grants-1996_08
Patentnummer
US05550121

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