(RS)-Salsolinol → alpha-(3,4-Dimethoxyphenyl)-3,4-dihydro-6,7-dihydroxy-1-methyl-alpha-[(4-methylphenyl)thio]-2(1H)-isoquinoline-pentanenitrile

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	(RS)-Salsolinol	HCID 54456	—
Edukt	alpha-(3-Chloropropyl)-3,4-dimethoxy-alpha-[(4-methylphenyl)-thio]benzeneacetonitrile	HCID 10738259	—
Produkt	alpha-(3,4-Dimethoxyphenyl)-3,4-dihydro-6,7-dihydroxy-1-methyl-alpha-[(4-methylphenyl)thio]-2(1H)-isoquinoline-pentanenitrile	HCID 10839653	18,3%

Reaktionsschritte

The procedure of Example 3 is repeated using 1.0 g of α-(3-chloropropyl)-3,4-dimethoxy-α-[(4-methylphenyl)thio]benzeneacetonitrile and 0.76 g of 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline. This affords 0.253 g of the desired product as a beige gum.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US05550149
Quelldatensatz	uspto-grants-1996_08
ORD ID	ord-84fb6fc2588d4b65b1c01733fbea9f0d
Quellennotiz	uspto-grants-1996_08