HCID 23366620, Verbindung → N-Benzoylbenzylamine

HRID 1079298

Reaktionsgleichung

Reaktionsgleichung von HRID 1079298
[C:1]([NH:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14](OC)=[CH:13][C:12]=1OC)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>FC(F)(F)C(O)=O>[C:1]([NH:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

3

Edukt 1

HCID 23366620HCID 23366620, Verbindung

Produkt 1

HCID 73878N-Benzoylbenzylamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

N-benzoyl-2,4-dimethoxybenzylamine (100 mg, 0.37 mmol) was dissolved in 1 ml 95% (v/v) trifluoroacetic acid (TFA) and stirred for 1 h at 20° C. TFA was removed by blowing with N2 and the residue suspended in methanol (1 ml). The reaction mixture was analyzed by TLC using CH2Cl2 /MeOH/AcOH (85:10:5) as eluent and the generated benzamide was determined quantitatively by HPLC using benzamide standard chromatograms.

Aufarbeitung

  1. customTFA was removed

Quellen und Nachweise

ORD-Eintrag
ord-559beeee2eff4a7388ab6c2ea27e7cde
Quelldatensatz
uspto-grants-1996_12
Patentnummer
US05580751

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