Sodium Carbonate → 2-(4'-Trifluoromethylphenyl)-6-hydroxybenzoxazole

HRID 1081229

Reaktionsgleichung

Reaktionsgleichung von HRID 1081229
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=[O:8])=[CH:5][CH:4]=1.[NH2:14][C:15]1[CH:21]=[CH:20][C:18]([OH:19])=[CH:17][C:16]=1O.C(=O)([O-])[O-].[Na+].[Na+]>>[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7]2[O:8][C:16]3[CH:17]=[C:18]([OH:19])[CH:20]=[CH:21][C:15]=3[N:14]=2)=[CH:5][CH:4]=1

Komponenten

4

Edukt 3

HCID 10340Sodium CarbonateHCID 676074-(Trifluoromethyl)benzoyl chlorideHCID 4328274-Aminoresorcinol

Produkt 1

HCID 214669512-(4'-Trifluoromethylphenyl)-6-hydroxybenzoxazole

Versuchsvorschrift

1.5 ml (10 mol) of 4-trifluoromethylbenzoyl chloride were heated to 190° C. in an oil bath and 1.6 g (10 mmol) of 4-aminoresorcinol were added in portions. After 1 hour the reaction mixture was introduced into 100 ml of 10% strength sodium carbonate solution and heated. The unreacted acid chloride was hydrolyzed during this procedure. The product was then extracted with ethyl acetate and purified by column chromatography (silica gel 60, ethyl acetate or chloroform/glacial acetic acid 9:1).

Aufarbeitung

  1. temperatureheated
  2. extractionThe product was then extracted with ethyl acetate
  3. custompurified by column chromatography (silica gel 60, ethyl acetate or chloroform/glacial acetic acid 9:1)

Quellen und Nachweise

ORD-Eintrag
ord-163e225a31e2416b9769e2adc0f2e040
Quelldatensatz
uspto-grants-1996_12
Patentnummer
US05585247

Verknüpfte Notizen

Wird geladen…