5-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine → 5-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine.hydrochloride

HRID 1081710

Reaktionsgleichung

Reaktionsgleichung von HRID 1081710
[CH3:1][S:2]([NH:5][CH2:6][CH2:7][S:8][C:9]1[N:14]2[CH:15]=[CH:16][N:17]=[C:13]2[CH:12]=[CH:11][CH:10]=1)(=[O:4])=[O:3].[ClH:18].CO>CO>[CH3:1][S:2]([NH:5][CH2:6][CH2:7][S:8][C:9]1[N:14]2[CH:15]=[CH:16][N:17]=[C:13]2[CH:12]=[CH:11][CH:10]=1)(=[O:4])=[O:3].[ClH:18]

Komponenten

4

Edukt 2

HCID 152293635-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridineHCID 21893726Hydrochloride methanol

Produkt 1

HCID 200866555-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine.hydrochlorideAusbeute 89,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A suspension of 5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine (543 g, 2 mmoles) in methanol (20 ml) was treated with hydrogen chloride-methanol. After the solvent was distilled off, the residue was crystallized from chloroform ether. Then, the crystals thus obtained were washed with ether and dried to obtain 550 mg of the desired product (89.3%, colorless crystals).

Aufarbeitung

  1. distillationAfter the solvent was distilled off
  2. customthe residue was crystallized from chloroform ether
  3. customThen, the crystals thus obtained
  4. washwere washed with ether
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-df264766d11c40e7b7945e674cf3610d
Quelldatensatz
uspto-grants-1996_12
Patentnummer
US05587383

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