Ammonia → 4-Methoxybenzamidine Hydrochloride

HRID 1082081

Reaktionsgleichung

Reaktionsgleichung von HRID 1082081
[ClH:1].CO[C:4](=[NH:13])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=1.[NH3:14]>CO>[ClH:1].[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:5]([C:4]([NH2:13])=[NH:14])=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 12463133Methyl 4-methoxybenzimidate hydrochloride

Produkt 1

HCID 123262194-Methoxybenzamidine Hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

35.9 g of 4-methoxybenzimidic acid methylester hydrochloride was dissolved in 300 ml of methanol. After saturation with ammonia gas under cooling in ice-water and stirring, the solution was stirred at room temperature for 15 hours. Then, methanol was evaporated in vacuo. Ethyl acetate was added to the residue. The precipitated crystals were filtered off and dried. Whereby 30.9 g of the desired substance was obtained as white crystals. Melting point is 220° to 221° C.

Aufarbeitung

  1. stirringthe solution was stirred at room temperature for 15 hours
  2. customThen, methanol was evaporated in vacuo
  3. additionEthyl acetate was added to the residue
  4. filtrationThe precipitated crystals were filtered off
  5. customdried
  6. customWhereby 30.9 g of the desired substance was obtained as white crystals

Quellen und Nachweise

ORD-Eintrag
ord-3445fba12d2a4bb7b66b3f276e7d1fab
Quelldatensatz
uspto-grants-1996_12
Patentnummer
US05589477

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