3-Chlorobenzaldehyde → alpha-Cyano-3'-chloro-3,4-dimethoxystilbene

HRID 1082255Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1082255
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][C:12]#[N:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[Cl:14][C:15]1[CH:16]=[C:17]([CH:20]=[CH:21][CH:22]=1)[CH:18]=O.[OH-].[Na+]>C(O)C>[C:12]([C:11](=[CH:18][C:17]1[CH:20]=[CH:21][CH:22]=[C:15]([Cl:14])[CH:16]=1)[C:5]1[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1)#[N:13]

Komponenten

5

Edukt 3

HCID 114773-ChlorobenzaldehydeHCID 14798Sodium HydroxideHCID 667273,4-Dimethoxybenzeneacetonitrile

Produkt 1

HCID 54124140alpha-Cyano-3'-chloro-3,4-dimethoxystilbeneAusbeute 78,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

3,4-dimethoxyphenylacetonitrile (purchased from Tokyo Kasei), 1.77 g (10.0 mmole), and 1.41 g (10.0 mmole) of 3-chlorobenzaldehyde (purchased from Tokyo Kasei) were dissolved with heating into 10 ml of ethanol (purchased from Kokusan Kagaku), two drops of a 20% sodium hydroxide solution were added thereto, the mixture was stirred overnight, and deposited crystals were filtered, washed with ethanol twice and subsequently with hexane twice and dried to obtain 2.35 g (yield: 78.3%) of α-cyano-3'-chloro-3,4-dimethoxystilbene (yellow crystal).

Aufarbeitung

  1. additionwere added
  2. filtrationwere filtered
  3. washwashed with ethanol twice
  4. dry with materialsubsequently with hexane twice and dried

Quellen und Nachweise

ORD-Eintrag
ord-f0786f1df4e1469c95147b176132d22e
Quelldatensatz
uspto-grants-1996_12
Patentnummer
US05589506

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