Methyl acetoacetate → Methyl 3-tetrahydropyrrolyl-2-butenoate

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

Methyl acetoacetate (20 g, 172.23 mmol) was dissolved in 250 mL of toluene, and then pyrrolidine (43 ml, 516.70 mmol) and p-toluenesulfonic acid hydrate (about 100 mg) were added dropwise. After installing a Dean-Stark separator to the reactor, the reaction mixture was refluxed 140° C. for two days, and then solvent was removed by concentrating the resulting mixture under a reduced pressure, thereby to obtain the desired product (29 g, 99%).

Herkunft & Nachweise