(3RS)-3-amino-1-ethoxycarbonylmethyl-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one → 5-(2-Fluorophenyl)-2,5-dihydro-3-((((1-methylethyl) amino)carbonyl)amino)-2-oxo-1H-1,4-benzodiazepine-1-acetic acid ethyl ester

HRID 1084566Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1084566
[NH2:1][CH:2]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[F:15])[C:6]2[CH:16]=[CH:17][CH:18]=[CH:19][C:5]=2[N:4]([CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])[C:3]1=[O:26]>O1CCCC1>[CH2:24]([O:23][C:21](=[O:22])[CH2:20][N:4]1[C:5]2[CH:19]=[CH:18][CH:17]=[CH:16][C:6]=2[CH:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[F:15])[N:8]=[C:2]([NH:1][C:3]([NH:4][CH:5]([CH3:19])[CH3:6])=[O:26])[C:3]1=[O:26])[CH3:25]

Komponenten

3

Edukt 1

HCID 10066773(3RS)-3-amino-1-ethoxycarbonylmethyl-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Produkt 1

HCID 541261305-(2-Fluorophenyl)-2,5-dihydro-3-((((1-methylethyl) amino)carbonyl)amino)-2-oxo-1H-1,4-benzodiazepine-1-acetic acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Equimolar amounts of 3(R,S)-amino-1,3-dihydro-1-ethoxycarbonylmethyl-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one and isoproplylisocyanate were mixed in 8 ml of dry tetrahydrofuran at room temperature. The reaction mixture was allowed to stand for 8 hours and was then filtered. The collected solids were washed with tetrahydrofuran and dried in vacuo over P2O5 to give the analytical product: m.p. 155°-157° C.

Aufarbeitung

  1. filtrationwas then filtered
  2. washThe collected solids were washed with tetrahydrofuran
  3. dry with materialdried in vacuo over P2O5
  4. customto give the analytical product

Quellen und Nachweise

ORD-Eintrag
ord-a48a6ecd5948498595ebaa979436e331
Quelldatensatz
uspto-grants-1991_04
Patentnummer
US05004741

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