Hydrochloric Acid → 2-(3,5-Dichlorophenyl)propan-2-amine

HRID 1084629Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1084629
[Cl:1][C:2]1[CH:3]=[C:4]([CH:11]=[C:12]([Cl:14])[CH:13]=1)[C:5]([NH:8]C=O)([CH3:7])[CH3:6].Cl.[OH-].[Na+]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:11]=[C:12]([Cl:14])[CH:13]=1)[C:5]([NH2:8])([CH3:6])[CH3:7]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15754135N-(3,5-dichloroalpha,alpha-dimethylbenzyl)formamide

Produkt 1

HCID 111950522-(3,5-Dichlorophenyl)propan-2-amineAusbeute 98 %

Versuchsvorschrift

A mixture of 1.16 g (5 mmol) of N-(3,5-dichloro,α,α-dimethylbenzyl)formamide and 8 ml of 2N hydrochloric acid was refluxed for 30 minute. After cooling, the reaction solution was alkalified with a sodium hydroxide aqueous solution and extracted with diethyl ether. The ether solution was washed with water, dried and then concentrated to obtain 1.0 g (yield: 98.0%) of the desired compound.

Aufarbeitung

  1. temperaturewas refluxed for 30 minute
  2. temperatureAfter cooling
  3. extractionextracted with diethyl ether
  4. washThe ether solution was washed with water
  5. customdried
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-a0374ac6c9b247f4ba249b9919659d8e
Quelldatensatz
uspto-grants-1991_04
Patentnummer
US05006157

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