Methanol → 7-(Hydroxyphenylmethyl)-3-hydroxy-2-phenyl-6-azabenzo[b]thiophene

HRID 1084741Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1084741
[OH:1][CH:2]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:3]1[C:8]2[S:9][C:10]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[C:11](COC)[C:7]=2[CH:6]=[CH:5][N:4]=1.C[OH:28]>Cl>[OH:1][CH:2]([C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[C:3]1[C:8]2[S:9][C:10]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[C:11]([OH:28])[C:7]=2[CH:6]=[CH:5][N:4]=1

Komponenten

4

Edukt 2

HCID 887MethanolHCID 200626177-(Hydroxyphenylmethyl)-3-methoxymethyl-2-phenyl-6-azabenzo[b]thiophene

Produkt 1

HCID 142776407-(Hydroxyphenylmethyl)-3-hydroxy-2-phenyl-6-azabenzo[b]thiopheneAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

A solution of 0.61 g (1.8 mmol) of 7-(hydroxyphenylmethyl)-3-methoxymethyl-2-phenyl-6-azabenzo[b]thiophene in 2.7 mL of 2M HCl and 2.7 mL of methanol was heated at reflux for 30 minutes. The solution was cooled and partitioned between ethyl aoetate and water. The ethyl acetate layer was dried and concentrated to afford 0.50 g (93%) of white solid, m.p. 214-215° C.

Aufarbeitung

  1. temperatureat reflux for 30 minutes
  2. temperatureThe solution was cooled
  3. custompartitioned between ethyl aoetate and water
  4. dry with materialThe ethyl acetate layer was dried
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-50cd0fe8dd1a450293e03bc8f529ba1c
Quelldatensatz
uspto-grants-1991_04
Patentnummer
US05006532

Notizen zur Reaktion

Wird geladen…