Triethylamine → 1,3-Dimethyl-6-(piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione

HRID 1085259

Reaktionsgleichung

Reaktionsgleichung von HRID 1085259
[N+:1]([C:4]1[CH:15]=[CH:14][C:7](C(NCCBr)=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH3:16][N:17]1[C:22]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[CH:21][C:20](=[O:29])[N:19]([CH3:30])[C:18]1=[O:31].C(N(CC)CC)C>C(O)(C)C>[CH3:16][N:17]1[C:22]([N:23]2[CH2:28][CH2:27][N:26]([C:7]3[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:15][CH:14]=3)[CH2:25][CH2:24]2)=[CH:21][C:20](=[O:29])[N:19]([CH3:30])[C:18]1=[O:31].[CH3:16][N:17]1[C:22]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[CH:21][C:20](=[O:29])[N:19]([CH3:30])[C:18]1=[O:31]

Komponenten

6

Edukt 3

HCID 8471TriethylamineHCID 458985N-(2-Bromoethyl)-p-nitrobenzamideHCID 128168731,3-Dimethyl-6-(piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione

Produkt 2

HCID 128168731,3-Dimethyl-6-(piperazin-1-yl)pyrimidine-2,4(1H,3H)-dioneHCID 200610781,3-dimethyl-6-[4-(4-nitrophenyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

A mixture of 1.3 g of the compound 46 obtained in the paragraph (1), 1.8 g of 1,3-dimethyl-6-(1-piperazinyl)-2,4(1H,3H)pyrimidinedione (compound 37), 1.3 ml of triethylamine and 10 ml of isopropanol was heated under reflux for 3 hours.

Quellen und Nachweise

ORD-Eintrag
ord-2bd4fbbbc3894fdaabbf7c5db9213d68
Quelldatensatz
uspto-grants-1991_04
Patentnummer
US05008267

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