Ethanolamine → HCID 20061116, Verbindung

HRID 1085295Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1085295
Cl[C:2]1[N:7]([CH3:8])[C:6](=[O:9])[N:5]([CH3:10])[C:4](=[O:11])[C:3]=1[CH3:12].[CH2:13]([CH2:15][NH2:16])[OH:14].C(N(CC)CC)C>C(O)(C)C>[OH:14][CH2:13][CH2:15][NH:16][C:2]1[N:7]([CH3:8])[C:6](=[O:9])[N:5]([CH3:10])[C:4](=[O:11])[C:3]=1[CH3:12]

Komponenten

5

Edukt 3

HCID 700EthanolamineHCID 8471TriethylamineHCID 132969876-Chloro-1,3,5-trimethyl-2,4(1H,3H)-pyrimidinedione

Produkt 1

HCID 20061116HCID 20061116, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

6-chloro-1,3,5-trimethyl-2,4(1H,3H)-pyrimidinedione (3.4 g) was suspended in 30 ml of isopropanol, and the suspension was added with 1.26 ml of ethanolamine and 3.8 ml of triethylamine and then the resultant mixture was refluxed for 3 hours. The reaction mixture was allowed to stand overnight at room temperature, and thereafter crystals formed were collected by filtration, washed with water and then recrystallized using a water-ethanol solution (1:1, v/v), thereby 2.9 g of 6-(2-hydroxyethylamino)-1,3,5-trimethyl-2,4(1H,3H)-pyrimidinedione being obtained.

Aufarbeitung

  1. customcrystals formed
  2. filtrationwere collected by filtration
  3. washwashed with water
  4. customrecrystallized

Quellen und Nachweise

ORD-Eintrag
ord-2186b3e1ff814175b7218f41cd376278
Quelldatensatz
uspto-grants-1991_04
Patentnummer
US05008267

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