Hydrochloric Acid → 6-(4-Hydroxypiperidino)carbostyril hydrochloride

HRID 1085469Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1085469
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[NH:14][C:13](=[O:18])[CH:12]=[CH:11]3)[CH2:4][CH2:3]1.[ClH:19]>CO>[ClH:19].[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[NH:14][C:13](=[O:18])[CH:12]=[CH:11]3)[CH2:4][CH2:3]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 104669946-(4-Hydroxypiperidino)carbostyril

Produkt 1

HCID 200601536-(4-Hydroxypiperidino)carbostyril hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

6-(4-Hydroxypiperidino)carbostyril, 0.1 g (0.002 mole), was suspended in 15 mL methanol. Five mL ethanolic hydrogen chloride was added and the mixture digested on a steam bath for 15 minutes until part of the methanol had evaporated. After cooling, filtration and washing with ethyl acetate, the resulting white crystals, 0.05 g, were recrystallized by dissolving in warm methanol and adding ethyl acetate. The yield was 0.05 g 6-(4-hydroxypiperidino)carbostyril hydrochloride; m.p. 259°-262° C.

Aufarbeitung

  1. customhad evaporated
  2. temperatureAfter cooling
  3. filtrationfiltration
  4. washwashing with ethyl acetate
  5. customthe resulting white crystals, 0.05 g, were recrystallized
  6. dissolutionby dissolving in warm methanol
  7. additionadding ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-4ca302c327e341f686b861e62fdd0b24
Quelldatensatz
uspto-grants-1991_04
Patentnummer
US05010088

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