5'-Azido-2',5'-dideoxy-5-n-propyluridine → HCID 53664810, Verbindung

HRID 1085555

Reaktionsgleichung

Reaktionsgleichung von HRID 1085555
[N:1]([CH2:4][C@H:5]1[O:9][C@@H:8]([N:10]2[CH:17]=[C:16]([CH2:18][CH2:19][CH3:20])[C:14](=[O:15])[NH:13][C:11]2=[O:12])[CH2:7][C@@H:6]1[OH:21])=[N+]=[N-]>C(O)C.[Pd]>[NH2:1][CH2:4][C@H:5]1[O:9][C@@H:8]([N:10]2[CH:17]=[C:16]([CH2:18][CH2:19][CH3:20])[C:14](=[O:15])[NH:13][C:11]2=[O:12])[CH2:7][C@@H:6]1[OH:21]

Komponenten

4

Edukt 1

HCID 539281315'-Azido-2',5'-dideoxy-5-n-propyluridine

Produkt 1

HCID 53664810HCID 53664810, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

0.38 g of 5'-azido-2',5'-dideoxy-5-n-propyluridine was dissolved in 100 ml of ethanol and the solution was hydrogenated in the presence of 0.1 g of 10% palladium-on-charcoal catalyst for 2 hours at room temperature and under atmospheric pressure. The catalyst was removed by filtration and the filtrate was evaporated to give 5'-amino-2',5'-dideoxy-5-n-propyluridine in the form of a solid which was used without further purification.

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-d8f0a7bb96124d45b2d7b6cfe1ae6b48
Quelldatensatz
uspto-grants-1991_04
Patentnummer
US05010060

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