3-Nitrophthalic anhydride → Ethyl 3-(4-nitro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methyl-[1,3]dioxolan-2-yl)propionate

HRID 10856

Reaktionsgleichung

Reaktionsgleichung von HRID 10856
[NH2:1][CH2:2][CH:3]([C:9]1([CH3:14])[O:13][CH2:12][CH2:11][O:10]1)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[N+:15]([C:18]1[CH:28]=[CH:27][CH:26]=[C:20]2[C:21]([O:23][C:24](=O)[C:19]=12)=[O:22])([O-:17])=[O:16]>>[N+:15]([C:18]1[CH:28]=[CH:27][CH:26]=[C:20]2[C:19]=1[C:24](=[O:23])[N:1]([CH2:2][CH:3]([C:9]1([CH3:14])[O:10][CH2:11][CH2:12][O:13]1)[C:4]([O:6][CH2:7][CH3:8])=[O:5])[C:21]2=[O:22])([O-:17])=[O:16]

Komponenten

3

Edukt 2

HCID 216313-Nitrophthalic anhydrideHCID 21982228Ethyl 3-amino-2-(2-methyl-[1,3]dioxolan-2-yl)propionate

Produkt 1

HCID 21982203Ethyl 3-(4-nitro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methyl-[1,3]dioxolan-2-yl)propionate

Versuchsvorschrift

Ethyl 3-(4-nitro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methyl-[1,3]dioxolan-2-yl)propionate was prepared (0.64 g, 51%) in the same manner as described in the above example 5 (20) from ethyl 3-amino-2-(2-methyl-[1,3]dioxolan-2-yl)propionate (0.68 g, 3.34 mmol) and 3-nitrophthalic anhydride (0.84 g, 4.33 mmol), and the obtained product was identified with the following NMR data.

Quellen und Nachweise

ORD-Eintrag
ord-a8f84cf070604788a184785d3e608165
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094908B2

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