Hydrochloric Acid → 2-(1H-imidazol-1-ylmethyl)cyclopentanone
Reaktionsgleichung
C1O[C:4]2([CH2:8][CH2:7][CH2:6][CH:5]2[CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)[O:3]C1.Cl.[OH-].[K+]>>[N:10]1([CH2:9][CH:5]2[CH2:6][CH2:7][CH2:8][C:4]2=[O:3])[CH:14]=[CH:13][N:12]=[CH:11]1Komponenten
4
Reaktionsbedingungen
- Temperatur
- 60 °C
Versuchsvorschrift
In an oil bath, 3.5603 g of 2-(lH-imidazol-1-ylmethyl)cyclopentanone ethyleneketal (IV) and 17.8 ml of 2N hydrochloric acid added thereto were stirred at 60° C. for 5 hours. The resultant reaction solution was left cooling. Then, it was neutralized with an aqueous 1N potassium hydroxide solution and extracted with methylene chloride, to obtain an organic layer. This organic layer was washed with water, dried over anhydrous sodium sulfate, and evaporated under a reduced pressure.