Chloroacetyl chloride → HCID 86744750, Verbindung

HRID 1085854

Reaktionsgleichung

Reaktionsgleichung von HRID 1085854
C(O[CH2:4][CH2:5][NH:6][C:7]1[C:12]([N+:13]([O-:15])=[O:14])=[CH:11][CH:10]=[CH:9][N:8]=1)C.ClCC(Cl)=[O:19].[O:21]1[CH2:26][CH2:25]O[CH2:23][CH2:22]1>>[CH2:22]([O:21][CH2:26][CH2:25][CH2:4][C:5]([NH:6][C:7]1[C:12]([N+:13]([O-:15])=[O:14])=[CH:11][CH:10]=[CH:9][N:8]=1)=[O:19])[CH3:23]

Komponenten

4

Edukt 3

HCID 6577Chloroacetyl chlorideHCID 312751,4-DioxaneHCID 15718757N-(2-Ethoxyethyl)-3-nitropyridin-2-amine

Produkt 1

HCID 86744750HCID 86744750, Verbindung

Versuchsvorschrift

To a stirred solution of 42.24 parts of N-(2-ethoxyethyl)-3-nitro-2-pyridinamine in 309 parts of 1,4-dioxane were added 49.7 parts of 2-chloroacetyl chloride. The reaction mixture was stirred for 4 hours at reflux temperature. The whole was evaporated and the residue was taken up in methylbenzene. The organic layer was evaporated again, yielding 57.5 parts (100%) of 2-chloro-N-(2-ethoxyethyl-N-(3-nitro-2-pyridinyl)acetamide as a residue (int. 1).

Aufarbeitung

  1. temperatureat reflux temperature
  2. customThe whole was evaporated
  3. customThe organic layer was evaporated again

Quellen und Nachweise

ORD-Eintrag
ord-5afc742947b948d688aa0b360f215e15
Quelldatensatz
uspto-grants-1991_04
Patentnummer
US05011842

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