5'-fluoro-N-methyl-2'-methylsulphinylacetylformanilide → Flosequinan

Beteiligte Stoffe

Reaktionsschritte

A solution of 5'-fluoro-N-methyl-2'-methylsulphinylacetylformanilide (0.77 g) in 2-methoxyethanol (25 ml) was heated to reflux over 20 minutes. After heating under reflux at 128° for 45 minutes the mixture was evaporated in vacuo to give 7-fluoro-1-methyl-3-methylsulphinyl-4-quinolone, m.p.225.5°-227° (0.69 g).

Herkunft & Nachweise