4-Acetylpyridine → 4-Trifluoromethylbenzoic acid [1-(4pyridinyl)ethylidene]hydrazide

HRID 1085957

Reaktionsgleichung

Reaktionsgleichung von HRID 1085957
[C:1]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)(=O)[CH3:2].[F:10][C:11]([F:23])([F:22])[C:12]1[CH:21]=[CH:20][C:15]([C:16]([NH:18][NH2:19])=[O:17])=[CH:14][CH:13]=1>C(O)C>[N:7]1[CH:8]=[CH:9][C:4]([C:1](=[N:19][NH:18][C:16](=[O:17])[C:15]2[CH:14]=[CH:13][C:12]([C:11]([F:10])([F:23])[F:22])=[CH:21][CH:20]=2)[CH3:2])=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 142824-AcetylpyridineHCID 5206624-(Trifluoromethyl)benzohydrazide

Produkt 1

HCID 538678224-Trifluoromethylbenzoic acid [1-(4pyridinyl)ethylidene]hydrazideAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 2.97 gm (0.0245 mole) of 4-acetylpyridine, 5.0 gm (0.0245 mole) of 4-trifluoromethylbenzhydrazide and 100 ml of absolute ethanol is refluxed for 6 hr. The hot solution is filtered. The filtrate is diluted with water to the cloud point, cooled to room temperature and chilled. The crystals which separate are collected, washed with water and dried to yield 6.29 gm (84%) of the title compound having a melting point of 198.4° C.

Aufarbeitung

  1. temperatureis refluxed for 6 hr
  2. filtrationThe hot solution is filtered
  3. additionThe filtrate is diluted with water to the cloud point
  4. temperaturechilled
  5. customThe crystals which separate
  6. customare collected
  7. washwashed with water
  8. customdried

Quellen und Nachweise

ORD-Eintrag
ord-fa282594d35946fd91d63e933799e28c
Quelldatensatz
uspto-grants-1991_04
Patentnummer
US05011932

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