Sodium Carbonate → 3,6,8-Tribromoimidazo[1,2-a]pyrazine

HRID 1086174Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1086174
[Br:1][C:2]1[N:3]=[C:4]([Br:11])[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1.[Br:12]N1C(=O)CCC1=O.C([O-])([O-])=O.[Na+].[Na+]>C(Cl)(Cl)Cl>[Br:12][C:8]1[N:6]2[CH:7]=[C:2]([Br:1])[N:3]=[C:4]([Br:11])[C:5]2=[N:10][CH:9]=1

Komponenten

5

Edukt 3

HCID 10340Sodium CarbonateHCID 67184N-bromobutanimideHCID 150258436,8-Dibromoimidazo[1,2-a]pyrazine

Produkt 1

HCID 142076223,6,8-Tribromoimidazo[1,2-a]pyrazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A solution of 0.8 g (2.9 mmol) of 6,8-dibromoimidazo[1,2-a]pyrazine and 1.2 g of N-bromosuccinimide in 40 ml of chloroform is brought to reflux for two hours. After being cooled, the organic solution is treated with aqueous Na2CO3 solution. The chloroform phase is collected and then evaporated. 1 g -(Yld=97%) of 3,6,8-tribromoimidazo[1,2-a]pyrazine (m.p. 161° C.) is obtained.

Aufarbeitung

  1. temperatureto reflux for two hours
  2. temperatureAfter being cooled
  3. customThe chloroform phase is collected
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-6ae912ba9eb44bfab634123c48a48334
Quelldatensatz
uspto-grants-1991_07
Patentnummer
US05028605

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