2-Chlorothiazole → 9-fluoro-5H-thiazolo-(2,3-b)-quinazolin-5-one
Reaktionsgleichung
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]([C:5]([NH2:7])=[O:6])[C:3]=1[NH2:11].Cl[C:13]1[S:14][CH:15]=[CH:16]N=1>>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]2[C:3]=1[N:11]=[C:13]1[S:14][CH:15]=[CH:16][N:7]1[C:5]2=[O:6]Komponenten
3
Versuchsvorschrift
15.4 g of 3-fluoroanthranilamide and 13.1 g of 2-chlorothiazole were stirred for 7 hours at 150° C. After working up in the conventional manner there was obtained 17.3 g (79%) of the above compound; m.p. 187°-189° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-31aa38c7c1994a8a9269c5d5ac9a8908
- Quelldatensatz
- uspto-grants-1991_07
- Patentnummer
- US05030727
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