(2R,3S,4S,5R)-2,3,4,5,6-pentahydroxyhexanal → Lactulose

HRID 1086962

Reaktionsgleichung

Reaktionsgleichung von HRID 1086962
[CH2:1]([OH:23])[C@H:2]1[O:7][C@@H:6]([O:8][C@H:9]2[C@H:13]([OH:14])[C@@:12]([OH:17])([CH2:15][OH:16])[O:11][C@@H:10]2[CH2:18][OH:19])[C@H:5]([OH:20])[C@@H:4]([OH:21])[C@H:3]1[OH:22].O.O=C[C@@H]([C@H]([C@H]([C@@H](CO)O)O)O)O>>[CH2:1]([OH:23])[C@H:2]1[O:7][C@@H:6]([O:8][C@H:9]2[C@H:13]([OH:14])[C@@:12]([OH:17])([CH2:15][OH:16])[O:11][C@@H:10]2[CH2:18][OH:19])[C@H:5]([OH:20])[C@@H:4]([OH:21])[C@H:3]1[OH:22]

Komponenten

3

Edukt 2

HCID 3037556(2R,3S,4S,5R)-2,3,4,5,6-pentahydroxyhexanalHCID 66964417(2S,3R,4S,5R,6R)-2-[(2R,3S,4S,5R)-4,5-dihydroxy-2,5-bis(hydroxymethyl)oxolan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;hydrate2×

Produkt 1

HCID 11333LactuloseAusbeute 50,4 %

Versuchsvorschrift

A lactulose syrup was prepared in a manner similar to Example 1 except that the chromatography was practiced using XT-1007 (product of Tokyo Organic Chemical Industry Co., Ltd.) (crosslinking degree: 0.6%) as an ion-exchange resin. The peak of lactulose-containing fractions occurred about 123 minutes after the initiation of charging, while the peak of fractions containing monosaccharides such as galactose appeared about 167 minutes after the initiation of charging. The lactulose-containing fractions were collected and concentrated into a syrup, which had the following saccharide composition: 94.3 wt. % of lactulose and 4.2 wt. % of lactose, both based on the whole solids. The solid weight of lactulose was 201.5 kg, and its yield was 50.4% based on the starting lactose.

Aufarbeitung

  1. waitappeared about 167 minutes
  2. customwere collected
  3. concentrationconcentrated into a syrup, which

Quellen und Nachweise

ORD-Eintrag
ord-d4d41a74b2f84f018596b0b82a748131
Quelldatensatz
uspto-grants-1991_07
Patentnummer
US05034064

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